ReadyBoost

Useful tweaks
Speed it up with a flash drive: Perhaps one of my favorite performance-improving strategies, using Windows Vista's new ReadyBoost technology, you can speed up your PC on the fly by simply plugging in a USB drive (or iPod or Compact Flash card or any external drive) with some spare megabytage.
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Windows ReadyBoost is a great technology, caching things on USB drives to improve system performance, but Windows Vista insists on checking the drives for certain speed requirements before enabling the feature. If you have a USB drive that is just a hair to slow to beat the test, or you want to use an external hard drive (slower speed, loads of cache space), how you can force Vista to let you use ReadyBoost on an unsupported device, whether it wants to or not:
• 1. Plug in the device.
• 2. Open the Readyboost tab on the device properties.
• 3. Select “Do not retest this device”
• 4. Unplug the device
• 5. Open regedit (start->run->regedit)
• 6. Expand - HKLM (Local Machine)SOFTWARE-Microsoft-Windows CurrentVersion-EMDgmt
• 7. Find your device.
• 8. Change Device Status to 2
• 9. Change ReadSpeedKBs to 1000
• 10. Change WriteSpeedKBs to 1000
• 11. Plug in the device.
• 12. Enable Readyboost!!!!
Try to see if it improves performance, especially when dedicated 30 gigabytes of an external drive to ReadyBoost, or if Microsoft’s speed test knows what it’s talking about.

Windows Vista's SuperFetch and ReadyBoost Analyzed Tom's Hardware